Ak7^{Tg(tetO-Hmox1)67Sami}
Transgenic Allele Detail

Summary

• Symbol: Ak7^{Tg(tetO-Hmox1)67Sami}
• Name: adenylate kinase 7; transgene insertion 67, S Alex Mitsialis
• MGI ID: MGI:5431002
• Synonyms: TH67
• Gene: Ak7 Location: Chr12:105672235-105748706 bp, + strand Genetic Position: Chr12, 55.95 cM, cytoband F1
• Alliance: Ak7^{Tg(tetO-Hmox1)67Sami} page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Null/knockout)
• Inducer: doxycycline/tetracycline
• Mutations: Insertion, Intragenic deletion
• Ak7^{Tg(tetO-Hmox1)67Sami} expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hmox1 (MGI:96163)

• Ak7^{Tg(tetO-Hmox1)67Sami} expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	tetO

• Mutation details: A transgene containing a tetracycline responsive promoter driving expression of Hmox1 inserted into intron 5 in line 67. A T:A base pair deletion was also detected in exon 4 that results in a frameshift mutation. RT-PCR confirmed the absence of endogenous gene transcript expression. (J:186062)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ak7 Mutation: 139 strains or lines available

References

• Original: J:186062 Fernandez-Gonzalez A, et al., Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype. Am J Respir Cell Mol Biol. 2009 Mar;40(3):305-13
• All: 1 reference(s)