Rock1^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Rock1^tm1Lex
• Name: Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1, Lexicon Genomics
• MGI ID: MGI:5431098
• Gene: Rock1 Location: Chr18:10064401-10182045 bp, - strand Genetic Position: Chr18, 4.91 cM, cytoband A2
• Alliance: Rock1^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186058
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• A lacZ/neo cassette replaced exons 3 and 4. (J:186058)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rock1 Mutation: 60 strains or lines available

References

• Original: J:186058 Whitlock NA, et al., Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK. J Ocul Pharmacol Ther. 2009 Jun;25(3):187-94
• All: 1 reference(s)