Cacna1d^tm1Hgn
Targeted Allele Detail

Summary

• Symbol: Cacna1d^tm1Hgn
• Name: calcium channel, voltage-dependent, L type, alpha 1D subunit; targeted mutation 1, Hans Gerd Nothwang
• MGI ID: MGI:5431126
• Synonyms: Cacna1d^fl
• Gene: Cacna1d Location: Chr14:29761898-30213113 bp, - strand Genetic Position: Chr14, 18.43 cM, cytoband B
• Alliance: Cacna1d^tm1Hgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185977
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP and L3 sites were inserted upstream of exon 2. An inverted EGFP, loxP site, FRT-flanked neo cassette and L3 site were inserted downstream of exon 2. (J:185977)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1d Mutation: 119 strains or lines available

References

• Original: J:185977 Satheesh SV, et al., Retrocochlear function of the peripheral deafness gene Cacna1d. Hum Mol Genet. 2012 Sep 1;21(17):3896-909
• All: 2 reference(s)