Ptbp2^tm1.1Rbd
Targeted Allele Detail

Summary

• Symbol: Ptbp2^tm1.1Rbd
• Name: polypyrimidine tract binding protein 2; targeted mutation 1.1, Robert B Darnell
• MGI ID: MGI:5431214
• Synonyms: Ptbp2^pDLTV1
• Gene: Ptbp2 Location: Chr3:119512391-119578115 bp, - strand Genetic Position: Chr3, 52.18 cM
• Alliance: Ptbp2^tm1.1Rbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185949
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 99 bp fragment was replaced with an EGFP gene and a self-excising ACNF cassette via homologous recombination. Western blot analysis of whole brain lysates from homozygous mice confirmed the absence of protein expression. GFP expression recapitulates endogenous gene expression. (J:185949)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptbp2 Mutation: 54 strains or lines available

References

• Original: J:185949 Licatalosi DD, et al., Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Genes Dev. 2012 Jul 15;26(14):1626-42
• All: 3 reference(s)