Clcn7^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Clcn7^tm1.1Lex
• Name: chloride channel, voltage-sensitive 7; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:5431240
• Gene: Clcn7 Location: Chr17:25352365-25381078 bp, + strand Genetic Position: Chr17, 12.53 cM, cytoband A3.3
• Alliance: Clcn7^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186049
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1. A neo cassette with a 3' loxP site was inserted downstream of exon 1. Cre mediated recombination removed the neo cassette. QRT-PCR confirmed the absence of the standard transcript in the liver, heart, lung, kidney, muscle, brain and bone (with or without marrow) and the absence of the alternative transcript in the liver, heart, lung, kidney, muscle and brain but not bone (with or without marrow). (J:186049)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcn7 Mutation: 42 strains or lines available

References

• Original: J:186049 Rajan I, et al., An alternative splicing variant in Clcn7-/- mice prevents osteopetrosis but not neural and retinal degeneration. Vet Pathol. 2011 May;48(3):663-75
• All: 2 reference(s)