Pla2g5^tm1.1Kiku
Targeted Allele Detail

Summary

• Symbol: Pla2g5^tm1.1Kiku
• Name: phospholipase A2, group V; targeted mutation 1.1, Kiyotaka Kugiyama
• MGI ID: MGI:5431474
• Gene: Pla2g5 Location: Chr4:138526558-138590784 bp, - strand Genetic Position: Chr4, 70.57 cM
• Alliance: Pla2g5^tm1.1Kiku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186024
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Cre-mediated recombination removed exon 4 and the neo cassette. RT-PCR confirmed the absence of transcript expression in the heart. (J:186024)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pla2g5 Mutation: 23 strains or lines available

References

• Original: J:186024 Yano T, et al., Group V secretory phospholipase A2 plays a pathogenic role in myocardial ischaemia-reperfusion injury. Cardiovasc Res. 2011 May 1;90(2):335-43
• All: 2 reference(s)