Notch1^tm2.1Rko
Targeted Allele Detail

Summary

• Symbol: Notch1^tm2.1Rko
• Name: notch 1; targeted mutation 2.1, Raphael Kopan
• MGI ID: MGI:5431503
• Gene: Notch1 Location: Chr2:26347914-26393834 bp, - strand Genetic Position: Chr2, 18.91 cM
• Alliance: Notch1^tm2.1Rko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186213
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cre-mediated recombination removed the first coding exon. (J:90392)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Notch1 Mutation: 117 strains or lines available

References

• Original: J:186213 Sparrow DB, et al., A mechanism for gene-environment interaction in the etiology of congenital scoliosis. Cell. 2012 Apr 13;149(2):295-306
• All: 3 reference(s)