Drosha^tm1Ghan
Targeted Allele Detail

Summary

• Symbol: Drosha^tm1Ghan
• Name: drosha, ribonuclease type III; targeted mutation 1, Gregory J Hannon
• MGI ID: MGI:5431545
• Synonyms: Drosha^flGI
• Gene: Drosha Location: Chr15:12824901-12935377 bp, + strand Genetic Position: Chr15, 5.99 cM
• Alliance: Drosha^tm1Ghan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:183487
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed inactivation cassette was inserted between exons 3 and 4. Cre-mediated recombination is required to achieve gene inactivation. (J:183487)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drosha Mutation: 96 strains or lines available

References

• Original: J:183487 Teta M, et al., Inducible deletion of epidermal Dicer and Drosha reveals multiple functions for miRNAs in postnatal skin. Development. 2012 Apr;139(8):1405-16
• All: 1 reference(s)