Tg(CD207-cre/ERT2)1Dhka
Transgene Detail

Summary

• Symbol: Tg(CD207-cre/ERT2)1Dhka
• Name: transgene insertion 1, Daniel H Kaplan
• MGI ID: MGI:5431679
• Synonyms: huLangerin-CreER^T2
• Transgene: Tg(CD207-cre/ERT2)1Dhka Location: unknown
• Alliance: Tg(CD207-cre/ERT2)1Dhka page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(CD207-cre/ERT2)1Dhka expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  CD207 (50489)

  Cd207

  (MGI:2180021)

• Mutation details: A cassette encoding an IRES-cre/ERT2 sequence was inserted in the 3' UTR of the human langerin (CD207) gene in the bacterial artificial chromosome (BAC) RP11-504O1 by homologous recombination. This generated a 61 kb fragment that was used to produce transgenic mice. (J:185586)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	CD207 (human) Summary of all recombinase alleles driven by CD207. Alliance human CD207 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:185586 Bobr A, et al., Autocrine/paracrine TGF-beta1 inhibits Langerhans cell migration. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10492-7
• All: 5 reference(s)