Trp53^tm1.1Wgu
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1.1Wgu
• Name: transformation related protein 53; targeted mutation 1.1, Wei Gu
• MGI ID: MGI:5431727
• Synonyms: p53^K117R
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1.1Wgu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186159
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 4 was replaced with a modified exon 4 in which nucleotide substitutions (AG-to-GA) result in the amino acid substitution of lysine with arginine at position 117 (p.K117R). A loxP site flanked neomycin resistance gene cassette inserted downstream of the modified exon 4 was removed by Cre-mediated recombination. (J:186159)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:186159 Li T, et al., Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell. 2012 Jun 8;149(6):1269-83
• All: 3 reference(s)