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Trp53tm2.1Wgu
Targeted Allele Detail
Summary
Symbol: Trp53tm2.1Wgu
Name: transformation related protein 53; targeted mutation 2.1, Wei Gu
MGI ID: MGI:5431730
Synonyms: p533KR
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm2.1Wgu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:186159
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExons 4 and 5 were replaced with modified ones in which nucleotide substitutions results in the amino acid substitutions of lysine with arginine at positions 117, 161 and 162 (p.K117R (c.350_351delAGinsGA), p.K161R and p.K162R (c.482_486delAGAAGinsGGAGA). A loxP site flanked neomycin resistance gene cassette inserted between the two modified exons was removed by Cre-mediated recombination. (J:186159)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  239 strains or lines available
References
Original:  J:186159 Li T, et al., Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell. 2012 Jun 8;149(6):1269-83
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory