Trp53tm2.1Wgu
Targeted Allele Detail
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Symbol: |
Trp53tm2.1Wgu |
Name: |
transformation related protein 53; targeted mutation 2.1, Wei Gu |
MGI ID: |
MGI:5431730 |
Synonyms: |
p533KR |
Gene: |
Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
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Alliance: |
Trp53tm2.1Wgu page
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Germline Transmission: |
Earliest citation of germline transmission:
J:186159
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Parent Cell Line: |
W4 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Not Applicable) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Exons 4 and 5 were replaced with modified ones in which nucleotide substitutions results in the amino acid substitutions of lysine with arginine at positions 117, 161 and 162 (p.K117R (c.350_351delAGinsGA), p.K161R and p.K162R (c.482_486delAGAAGinsGGAGA). A loxP site flanked neomycin resistance gene cassette inserted between the two modified exons was removed by Cre-mediated recombination.
(J:186159)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trp53 Mutation: |
240 strains or lines available
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Original: |
J:186159 Li T, et al., Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell. 2012 Jun 8;149(6):1269-83 |
All: |
3 reference(s) |
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