Kcnq1ot1^tm2.1Ckan
Targeted Allele Detail

Summary

• Symbol: Kcnq1ot1^tm2.1Ckan
• Name: KCNQ1 overlapping transcript 1; targeted mutation 2.1, Chandrasekhar Kanduri
• MGI ID: MGI:5431827
• Synonyms: ICR^2lox
• Gene: Kcnq1ot1 Location: Chr7:142766848-142850284 bp, - strand Genetic Position: Chr7, 88.15 cM
• Alliance: Kcnq1ot1^tm2.1Ckan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185569
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the imprinting control and promoter region and a loxP site and FRT flanked neo cassette were inserted downstream of this region via homologous recombination. Flp mediated recombination removed the neo cassette. (J:185569)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnq1ot1 Mutation: 0 strains or lines available

References

• Original: J:185569 Mohammad F, et al., Long noncoding RNA-mediated maintenance of DNA methylation and transcriptional gene silencing. Development. 2012 Aug;139(15):2792-803
• All: 1 reference(s)