Vps18^tm1Wtao
Targeted Allele Detail

Summary

• Symbol: Vps18^tm1Wtao
• Name: VPS18 CORVET/HOPS core subunit; targeted mutation 1, Wufan Tao
• MGI ID: MGI:5431830
• Synonyms: Vps18^galeo
• Gene: Vps18 Location: Chr2:119119221-119128934 bp, + strand Genetic Position: Chr2, 59.97 cM
• Alliance: Vps18^tm1Wtao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186307
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutation: Insertion Mutation details: An FRT-flanked nuclear localized lacZ and neo cassette with 3' FRT and loxP sites were inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. (J:186307)

Generation of the Vps18^tm1Wtao and Vps18^tm1.1Wtao alleles

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
hm1	Vps18^tm1Wtao/Vps18^tm1Wtao	involves: 129S6/SvEvTac * C57BL/6

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
mortality/aging	√
preweaning lethality, complete penetrance	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vps18 Mutation: 34 strains or lines available

References

• Original: J:186307 Peng C, et al., Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem. 2012 Sep 21;287(39):32861-73
• All: 2 reference(s)