Drd2^tm3.1Ebo
Targeted Allele Detail

Summary

• Symbol: Drd2^tm3.1Ebo
• Name: dopamine receptor D2; targeted mutation 3.1, Emiliana Borrelli
• MGI ID: MGI:5431831
• Synonyms: D2R^flox
• Gene: Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
• Alliance: Drd2^tm3.1Ebo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185643
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette and left exon 2 floxed. (J:185643)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drd2 Mutation: 70 strains or lines available

References

• Original: J:185643 Anzalone A, et al., Dual Control of Dopamine Synthesis and Release by Presynaptic and Postsynaptic Dopamine D2 Receptors. J Neurosci. 2012 Jun 27;32(26):9023-9034
• All: 7 reference(s)