Rock2^{Gt(OST440776)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Rock2^{Gt(OST440776)Lex}
• Name: Rho-associated coiled-coil containing protein kinase 2; gene trap OST440776, Lexicon Genomics
• MGI ID: MGI:5431873
• Gene: Rock2 Location: Chr12:16944896-17037824 bp, + strand Genetic Position: Chr12, 8.04 cM, cytoband A3
• Alliance: Rock2^{Gt(OST440776)Lex} page

Mutation origin

• Mutant Cell Line: OST440776
• Germline Transmission: Earliest citation of germline transmission: J:186058
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector inserted between exon 1 and 2. RT-PCR confirmed the absence of transcript expression in the brain and eye. (J:186058)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rock2 Mutation: 60 strains or lines available

References

• Original: J:186058 Whitlock NA, et al., Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK. J Ocul Pharmacol Ther. 2009 Jun;25(3):187-94
• All: 1 reference(s)