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Thtm4.1Rpa
Targeted Allele Detail
Summary
Symbol: Thtm4.1Rpa
Name: tyrosine hydroxylase; targeted mutation 4.1, Richard D Palmiter
MGI ID: MGI:5431878
Synonyms: Thlox
Gene: Th  Location: Chr7:142446516-142453732 bp, - strand  Genetic Position: Chr7, 88.06 cM
Alliance: Thtm4.1Rpa page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:185955
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted 600 bp 5' of the transcription start site and a loxP site and FRT flanked neo cassette were inserted in intron 1 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:185955)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Th Mutation:  58 strains or lines available
References
Original:  J:185955 Jackson CR, et al., Retinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision. J Neurosci. 2012 Jul 4;32(27):9359-9368
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory