Th^tm4.1Rpa
Targeted Allele Detail

Summary

• Symbol: Th^tm4.1Rpa
• Name: tyrosine hydroxylase; targeted mutation 4.1, Richard D Palmiter
• MGI ID: MGI:5431878
• Synonyms: Th^lox
• Gene: Th Location: Chr7:142446516-142453732 bp, - strand Genetic Position: Chr7, 88.06 cM
• Alliance: Th^tm4.1Rpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185955
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 600 bp 5' of the transcription start site and a loxP site and FRT flanked neo cassette were inserted in intron 1 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:185955)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Th Mutation: 58 strains or lines available

References

• Original: J:185955 Jackson CR, et al., Retinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision. J Neurosci. 2012 Jul 4;32(27):9359-9368
• All: 12 reference(s)