Apc^tm1.1Klne
Targeted Allele Detail

Summary

• Symbol: Apc^tm1.1Klne
• Name: APC, WNT signaling pathway regulator; targeted mutation 1.1, Kristi L Neufeld
• MGI ID: MGI:5431889
• Synonyms: Apc^mNLS
• Gene: Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
• Alliance: Apc^tm1.1Klne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186132
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: Nucleotide substitutions replaced six amino acids in two nuclear localization sequences (NLS1 and NLS2) by substitution of alanine for lysine. A self-excising neo cassette was inserted into the last intron and removed itself properly. (J:186132)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Apc^tm1.1Klne

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apc Mutation: 158 strains or lines available

References

• Original: J:186132 Zeineldin M, et al., A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression. Oncogene. 2012 May 10;31(19):2423-37
• All: 3 reference(s)