Sfrp2^tm1.1Brle
Targeted Allele Detail

Summary

• Symbol: Sfrp2^tm1.1Brle
• Name: secreted frizzled-related protein 2; targeted mutation 1.1, Brendan Lee
• MGI ID: MGI:5431901
• Gene: Sfrp2 Location: Chr3:83673628-83681621 bp, + strand Genetic Position: Chr3, 37.37 cM
• Alliance: Sfrp2^tm1.1Brle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186306
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced by a loxP-flanked TK-neomycin cassette. Cre-mediated recombination removed the neo cassette. Northern blot analysis confirmed the absence of transcript expression. (J:186306)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sfrp2 Mutation: 30 strains or lines available

References

• Original: J:186306 Morello R, et al., Brachy-syndactyly caused by loss of Sfrp2 function. J Cell Physiol. 2008 Oct;217(1):127-37
• All: 5 reference(s)