Trp53tm1.1Rfo
Targeted Allele Detail
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Symbol: |
Trp53tm1.1Rfo |
Name: |
transformation related protein 53; targeted mutation 1.1, Riccardo Fodde |
MGI ID: |
MGI:5431904 |
Synonyms: |
p53P275S |
Gene: |
Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
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Alliance: |
Trp53tm1.1Rfo page
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Germline Transmission: |
Earliest citation of germline transmission:
J:186114
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Parent Cell Line: |
E14 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Humanized sequence) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: A loxP site flanked neomycin resistance gene and STOP cassette was inserted into intron 1. Exon 8 was replaced with a modified exon 8 in which a C-to-T substitution results in the amino acid substitution of proline with serine at position 275 (p.P275S). This mutation corresponds to a proven UVB exposure mutational hostspot at human codon 278. Cre-mediated recombination removed the neo/STOP cassette.
(J:186114)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trp53 Mutation: |
240 strains or lines available
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Original: |
J:186114 Voskamp P, et al., Rapamycin impairs UV induction of mutant-p53 overexpressing cell clusters without affecting tumor onset. Int J Cancer. 2012 Sep 15;131(6):1267-76 |
All: |
1 reference(s) |
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