Azgp1^tm1.1Sbah
Targeted Allele Detail

Summary

• Symbol: Azgp1^tm1.1Sbah
• Name: alpha-2-glycoprotein 1, zinc; targeted mutation 1.1, Seiamak Bahram
• MGI ID: MGI:5431920
• Synonyms: ZAP^-
• Gene: Azgp1 Location: Chr5:137979783-137988495 bp, + strand Genetic Position: Chr5, 76.92 cM
• Alliance: Azgp1^tm1.1Sbah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118213
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons alpha 1 and 2 were replaced with a floxed neo cassette. Cre mediated recombination removed the neo cassette. Western blot analysis confirmed the absence of protein expression in liver, kidney, fat depots, serum, heart, lung, stomach, intestine, spleen, brain and testis. (J:118213)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Azgp1 Mutation: 16 strains or lines available

References

• Original: J:118213 Rolli V, et al., Lipolysis is altered in MHC class I zinc-alpha(2)-glycoprotein deficient mice. FEBS Lett. 2007 Feb 6;581(3):394-400
• All: 2 reference(s)