Tert^tm3Rdp
Targeted Allele Detail

Summary

• Symbol: Tert^tm3Rdp
• Name: telomerase reverse transcriptase; targeted mutation 3, Ronald DePinho
• MGI ID: MGI:5431942
• Synonyms: LSL-mTert
• Gene: Tert Location: Chr13:73775030-73797962 bp, + strand Genetic Position: Chr13, 40.12 cM
• Alliance: Tert^tm3Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186105
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• A floxed neo stop cassette was inserted into intron 1 via homologous recombination. (J:186105)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tert Mutation: 55 strains or lines available

References

• Original: J:186105 Ding Z, et al., Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell. 2012 Mar 2;148(5):896-907
• All: 2 reference(s)