Tg(Mpz/GJB1-Prx*)#Brp
Transgene Detail

Summary

• Symbol: Tg(Mpz/GJB1-Prx*)#Brp
• Name: transgene insertion, Peter J Brophy
• MGI ID: MGI:5431952
• Synonyms: PrxdeltaTg
• Transgene: Tg(Mpz/GJB1-Prx*)#Brp Location: unknown
• Alliance: Tg(Mpz/GJB1-Prx*)#Brp page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mpz/GJB1-Prx*)#Brp expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prx (MGI:108176)

• Mutation details: The rat Mpz promoter was fused to the human GJB1 promoter to achieve Schwann cell-specific expression of the mouse cDNA lacking the sequence encoding amino acids 130 to 199 (the Drp2 binding site). An N-terminal FLAG tag was added to the mouse cDNA. The pound symbol (#) is used when no line is specified and or lines are pooled. (J:185953)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:185953 Sherman DL, et al., Drp2 and periaxin form cajal bands with dystroglycan but have distinct roles in schwann cell growth. J Neurosci. 2012 Jul 4;32(27):9419-28
• All: 1 reference(s)