Vps18^tm1.1Wtao
Targeted Allele Detail

Summary

• Symbol: Vps18^tm1.1Wtao
• Name: VPS18 CORVET/HOPS core subunit; targeted mutation 1.1, Wufan Tao
• MGI ID: MGI:5431976
• Synonyms: Vsp18^F
• Gene: Vps18 Location: Chr2:119119221-119128934 bp, + strand Genetic Position: Chr2, 59.97 cM
• Alliance: Vps18^tm1.1Wtao page

Small size of Vps18^tm1.1Wtao/Vps18^tm1.1Wtao Tg(Nes-cre)1Kln/0 mice at P10

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186307
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: Flp-mediated recombination removed the lacZ reporter gene and neo cassette. Exons 3 and 4 remain floxed. (J:186307)

Generation of the Vps18^tm1Wtao and Vps18^tm1.1Wtao alleles

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Vps18 Mutation: 34 strains or lines available

References

• Original: J:186307 Peng C, et al., Ablation of vacuole protein sorting 18 (Vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem. 2012 Sep 21;287(39):32861-73
• All: 2 reference(s)