Egln3^tm2Fong
Targeted Allele Detail

Summary

• Symbol: Egln3^tm2Fong
• Name: egl-9 family hypoxia-inducible factor 3; targeted mutation 2, Guo-Hua Fong
• MGI ID: MGI:5431993
• Synonyms: Egln3^fl, Egln3^floxN, PHD3^fl
• Gene: Egln3 Location: Chr12:54225767-54250646 bp, - strand Genetic Position: Chr12, 22.9 cM
• Alliance: Egln3^tm2Fong page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114669
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An additional loxP site and a neo cassette were inserted downstream of exon 2. This allele was used to generate Egln3^tm1Fong. (J:114669)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Egln3 Mutation: 26 strains or lines available

References

• Original: J:114669 Takeda K, et al., Placental but Not Heart Defects Are Associated with Elevated Hypoxia-Inducible Factor {alpha} Levels in Mice Lacking Prolyl Hydroxylase Domain Protein 2. Mol Cell Biol. 2006 Nov;26(22):8336-46
• All: 31 reference(s)