Tg(Ly6e-MALT1)#Isg
Transgene Detail
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Symbol: |
Tg(Ly6e-MALT1)#Isg |
Name: |
transgene insertion, Isidro Sanchez-Garcia |
MGI ID: |
MGI:5432016 |
Synonyms: |
Sca1-MALT1 |
Transgene: |
Tg(Ly6e-MALT1)#Isg Location: unknown
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Alliance: |
Tg(Ly6e-MALT1)#Isg page
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Tg(Ly6e-MALT1)#Isg/0 mice develop extranodal mucosa-associated lymphoid tissue lymphomas
Show the 7 phenotype image(s) involving this allele.
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Strain of Origin: |
C57BL/6 x CBA
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Ly6e-MALT1)#Isg expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
MALT1 (10892) |
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Mutation details: The mouse Ly6a promoter drives expression of the human MALT1 gene in the hematopoietic stem/progenitor cell compartment. Three lines (86A, 86B, 86C) were generated with 2 - 4 copies of the transgene inserted. RT-PCR and western blot analysis confirmed that transgene expression is restricted to Sca1+Lin- cells.
(J:185590)
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Schematic of the Tg(Ly6e-MALT1)#Isg transgene |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:185590 Vicente-Duenas C, et al., Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10534-9 |
All: |
1 reference(s) |
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