About   Help   FAQ
Tg(Ly6e-MALT1)#Isg
Transgene Detail
Summary
Symbol: Tg(Ly6e-MALT1)#Isg
Name: transgene insertion, Isidro Sanchez-Garcia
MGI ID: MGI:5432016
Synonyms: Sca1-MALT1
Transgene: Tg(Ly6e-MALT1)#Isg  Location: unknown  
Alliance: Tg(Ly6e-MALT1)#Isg page
Tg(Ly6e-MALT1)#Isg/0 mice develop extranodal mucosa-associated lymphoid tissue lymphomas

Show the 7 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  C57BL/6 x CBA
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ly6e-MALT1)#Isg expresses 1 gene
 
Mutation detailsThe mouse Ly6a promoter drives expression of the human MALT1 gene in the hematopoietic stem/progenitor cell compartment. Three lines (86A, 86B, 86C) were generated with 2 - 4 copies of the transgene inserted. RT-PCR and western blot analysis confirmed that transgene expression is restricted to Sca1+Lin- cells. (J:185590)
Schematic of the Tg(Ly6e-MALT1)#Isg transgene
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:185590 Vicente-Duenas C, et al., Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10534-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory