Tg(Camk2a-Grin2c/itTA)12Rsp
Transgene Detail

Summary

• Symbol: Tg(Camk2a-Grin2c/itTA)12Rsp
• Name: transgene insertion 12, Rolf Sprengel
• MGI ID: MGI:5432029
• Synonyms: Tg^CN12-itTA
• Transgene: Tg(Camk2a-Grin2c/itTA)12Rsp Location: unknown
• Alliance: Tg(Camk2a-Grin2c/itTA)12Rsp page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence, Transactivator)
• Mutation: Insertion
• Tg(Camk2a-Grin2c/itTA)12Rsp expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Grin2c (MGI:95822)

• Mutation details: The 8.5 kb promoter drives expression of the first three exons of the mouse gene, including a neuron-restrictive silencer element (NRSE), fused to an improved tetracycline transactivator (itTA) with a polyadenylation signal from the human growth hormone gene. Line 10 and 12 were generated. Line 12 exhibit more forebrain expression. (J:96556, J:103689)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:103689 Shimshek DR, et al., Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors. PLoS Biol. 2005 Nov;3(11):e354
• All: 5 reference(s)