Trim72^tm1Ygko
Targeted Allele Detail

Summary

• Symbol: Trim72^tm1Ygko
• Name: tripartite motif-containing 72; targeted mutation 1, Young-Gyu Ko
• MGI ID: MGI:5432128
• Synonyms: MG53^-
• Gene: Trim72 Location: Chr7:127603121-127610205 bp, + strand Genetic Position: Chr7, 69.89 cM
• Alliance: Trim72^tm1Ygko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186368
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 through 3 were replaced with a neo cassette. Western blot analysis confirmed the absence of protein expression in skeletal muscle. (J:186368)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
Loading...
hm1	Trim72^tm1Ygko/Trim72^tm1Ygko	Not Specified

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
muscle	√
abnormal myogenesis	√
centrally nucleated skeletal muscle fibers	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim72 Mutation: 34 strains or lines available

References

• Original: J:186368 Lee CS, et al., TRIM72 negatively regulates myogenesis via targeting insulin receptor substrate-1. Cell Death Differ. 2010 Aug;17(8):1254-65
• All: 3 reference(s)