Grm1^{Tg(p18A4.B)1352Szc}
Transgenic Allele Detail

Summary

• Symbol: Grm1^{Tg(p18A4.B)1352Szc}
• Name: glutamate receptor, metabotropic 1; transgene insertion 1352, Suzie Chen
• MGI ID: MGI:5432227
• Synonyms: TG3
• Gene: Grm1 Location: Chr10:10561803-10958100 bp, - strand Genetic Position: Chr10, 3.44 cM, cytoband A2
• Alliance: Grm1^{Tg(p18A4.B)1352Szc} page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The transgene contained a 2 kb segment of human cosmid p18A4 (known as Clone B; abbreviated here as p18A4.B). Line 1352 contains 3 copies of the transgene that insert into intron 3 and result in a 70 kb deletion within intron 3. Western blot analysis confirmed ectopic expression in melanoma tumors. (J:11894, J:83183)
• Inheritance: Semidominant

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grm1 Mutation: 81 strains or lines available

References

• Original: J:32786 Chen S, et al., Spontaneous melanocytosis in transgenic mice. J Invest Dermatol. 1996 May;106(5):1145-51
• All: 7 reference(s)