Tg(Gcg-icre)12Fmgb
Transgene Detail

Summary

• Symbol: Tg(Gcg-icre)12Fmgb
• Name: transgene insertion 12, Fiona M Gribble
• MGI ID: MGI:5432481
• Synonyms: GLU-Cre12
• Transgene: Tg(Gcg-icre)12Fmgb Location: unknown
• Alliance: Tg(Gcg-icre)12Fmgb page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Gcg-icre)12Fmgb expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gcg (MGI:95674)

• Mutation details: The sequence for icre was inserted into a BAC (RP23-343C17) by recombineering techniques, replacing the sequence between the start codon in exon 2 of the Gcg (glucagon; proglucagon) locus and the stop codon in exon 6. The modified BAC was purified and injected into fertilized oocytes. Four founder lines were established initially and copy numbers were determined (line: 01, 7-8 copies; 12, 2-3; 14, 1; 30, 1). Line 12 was analyzed in detail in the publication. (J:186436)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gcg (mouse) Summary of all recombinase alleles driven by Gcg. Comparative matrix view of recombinase activities Alliance mouse Gcg gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:186436 Parker HE, et al., Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion. Diabetologia. 2012 Sep;55(9):2445-55
• All: 16 reference(s)