Spo11^tm1Bdm
Targeted Allele Detail

Summary

• Symbol: Spo11^tm1Bdm
• Name: SPO11 initiator of meiotic double stranded breaks; targeted mutation 1, Bernard de Massy
• MGI ID: MGI:5432496
• Synonyms: Spo11Y138F, Spo11^YF
• Gene: Spo11 Location: Chr2:172819493-172835369 bp, + strand Genetic Position: Chr2, 95.64 cM, cytoband H4
• Alliance: Spo11^tm1Bdm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:199075
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Single point mutation Mutation details: Exon 5 was replaced by a modified exon 5 in which nucleotide substitution of a single A to T results in the amino acid substitution of phenylalanine for tyrosine at position 138 (Y138F). Two lox sites also remain inserted (one in intron 4, one in intron 9) after integration of the modified exon 5. (J:199075)

Generation of the Spo11^tm1Bdm allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spo11 Mutation: 21 strains or lines available

References

• Original: J:199075 Carofiglio F, et al., SPO11-independent DNA repair foci and their role in meiotic silencing. PLoS Genet. 2013 Jun;9(6):e1003538
• All: 2 reference(s)