Fcgr2b^tm1.2Rav
Targeted Allele Detail

Summary

• Symbol: Fcgr2b^tm1.2Rav
• Name: Fc receptor, IgG, low affinity IIb; targeted mutation 1.2, Jeffrey V Ravetch
• MGI ID: MGI:5432537
• Gene: Fcgr2b Location: Chr1:170786186-170804116 bp, - strand Genetic Position: Chr1, 78.02 cM
• Alliance: Fcgr2b^tm1.2Rav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174675
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the exon encoding the first extracellular domain. A floxed neo cassette was inserted downstream of the exon encoding the transmembrane domain. Cre mediated recombination removed the neo cassette and the exons. (J:174675, J:209892)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcgr2b Mutation: 49 strains or lines available

References

• Original: J:174675 Li F, et al., Inhibitory Fcgamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. Science. 2011 Aug 19;333(6045):1030-4
• All: 7 reference(s)