Tg(Ednrb-icre)#Lby
Transgene Detail

Summary

• Symbol: Tg(Ednrb-icre)#Lby
• Name: transgene insertion, Patricia A Labosky
• MGI ID: MGI:5432801
• Synonyms: Ednrb-iCre
• Transgene: Tg(Ednrb-icre)#Lby Location: unknown
• Alliance: Tg(Ednrb-icre)#Lby page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Ednrb-icre)#Lby expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Ednrb

• Mutation details: The 1 kb Ednrb enhancer (from -1.2 kb to -160 bp upstream of start site) was combined with the Hspa1b (Hsp68) minimal promoter to drive expression of codon-improved cre recombinase (icre). Transgenic mice were generated by standard microinjection techniques. Founder information or line number was not available. Recombination specificity was verified by crossing this line to ROSA26-lacz reporter mice. Beta-galactosidase staining was first detected in the developing gastrointestinal (GI) tract at E11.0. At E11.5, recombination was observed in enteric neural-crest progenitors in the GI tract along the length from esophagus to cecum and in the neural tube, but not in other neural crest derivatives (heart, skin, cranial or dorsal ganglia>) (J:182762)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ednrb (species not specified) Summary of all recombinase alleles driven by Ednrb.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:182762 Mundell NA, et al., Enteric nervous system specific deletion of Foxd3 disrupts glial cell differentiation and activates compensatory enteric progenitors. Dev Biol. 2012 Mar 15;363(2):373-87
• All: 1 reference(s)