Tespa1^tm1Smoc
Targeted Allele Detail

Summary

• Symbol: Tespa1^tm1Smoc
• Name: thymocyte expressed, positive selection associated 1; targeted mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:5432877
• Synonyms: Tespa1^tm1Lrgl
• Gene: Tespa1 Location: Chr10:130158696-130199338 bp, + strand Genetic Position: Chr10, 77.85 cM
• Alliance: Tespa1^tm1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186446
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced exon 2 and 3. Western blot analysis confirmed the absence of protein expression in thymocytes. (J:186446)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tespa1 Mutation: 33 strains or lines available

References

• Original: J:186446 Wang D, et al., Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nat Immunol. 2012 Jun;13(6):560-8
• All: 6 reference(s)