Tmem100^tm1.1Ysai
Targeted Allele Detail

Summary

• Symbol: Tmem100^tm1.1Ysai
• Name: transmembrane protein 100; targeted mutation 1.1, Yoshihiko Saito
• MGI ID: MGI:5432904
• Synonyms: Tmem100-lacZ
• Gene: Tmem100 Location: Chr11:89921174-89927334 bp, + strand Genetic Position: Chr11, 54.75 cM
• Alliance: Tmem100^tm1.1Ysai page

Abnormal cardiac morphology, pericardial effusion, and growth retardation in Tmem100^tm1.1Ysai and Acvrl1^tm1Dgen homozygotes

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186473
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: Exon 3 which includes the entire coding sequence was replaced with a lacZ gene and floxed neo cassette. Cre mediated recombination removed the neo cassette. (J:186473)

Generation of the Tmem100^tm1.1Ysai allele

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem100 Mutation: 15 strains or lines available

References

• Original: J:186473 Somekawa S, et al., Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12064-9
• All: 2 reference(s)