Tmem100^tm2.1Ysai
Targeted Allele Detail

Summary

• Symbol: Tmem100^tm2.1Ysai
• Name: transmembrane protein 100; targeted mutation 2.1, Yoshihiko Saito
• MGI ID: MGI:5432905
• Gene: Tmem100 Location: Chr11:89921174-89927334 bp, + strand Genetic Position: Chr11, 54.75 cM
• Alliance: Tmem100^tm2.1Ysai page

Impaired angiogenesis in Tmem100^tm1.1Ysai/Tmem100^tm2.1Ysai Tg(Tek-cre)1Ywa/0 embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186473
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 3. Flp mediated recombination removed the neo cassette leaving exon 3 floxed. (J:186473)

Generation of the Tmem100^tm2.1Ysai allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem100 Mutation: 15 strains or lines available

References

• Original: J:186473 Somekawa S, et al., Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12064-9
• All: 1 reference(s)