Rr19^tm1.1Nses
Targeted Allele Detail

Summary

• Symbol: Rr19^tm1.1Nses
• Name: regulatory region 19; targeted mutation 1.1, Nenad Sestan
• MGI ID: MGI:5433040
• Synonyms: E4^-
• Gene: Rr19 Location: unknown Genetic Position: Chr14, Syntenic
• Alliance: Rr19^tm1.1Nses page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186632
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The conserved non-exonic enhancer element (E4) upstream of Fezf2 was replaced with a loxP site flanked neomycin resistance gene cassette that was removed by subsequent cre-mediated recombination. qRT-PCR confirmed a severe reduction in Fezf2 transcript expression. (J:186632)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr19 Mutation: 0 strains or lines available

References

• Original: J:186632 Shim S, et al., Cis-regulatory control of corticospinal system development and evolution. Nature. 2012 Jun 7;486(7401):74-9
• All: 1 reference(s)