Foxp4^tm2.1Eem
Targeted Allele Detail

Summary

• Symbol: Foxp4^tm2.1Eem
• Name: forkhead box P4; targeted mutation 2.1, Edward E Morrisey
• MGI ID: MGI:5433099
• Synonyms: Foxp4^flox
• Gene: Foxp4 Location: Chr17:48178058-48235401 bp, - strand Genetic Position: Chr17, 23.99 cM, cytoband C
• Alliance: Foxp4^tm2.1Eem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:185603
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 12. An FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 13. Flp mediated recombination removed the neo cassette and left exons 12 and 13 floxed. (J:185603)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp4 Mutation: 91 strains or lines available

References

• Original: J:185603 Li S, et al., Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development. 2012 Jul;139(14):2500-9
• All: 6 reference(s)