Hspb8^tm1.1Depr
Targeted Allele Detail

Summary

• Symbol: Hspb8^tm1.1Depr
• Name: heat shock protein 8; targeted mutation 1.1, Christophe Depre
• MGI ID: MGI:5433119
• Gene: Hspb8 Location: Chr5:116546550-116560923 bp, - strand Genetic Position: Chr5, 56.41 cM
• Alliance: Hspb8^tm1.1Depr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186292
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and a floxed neo cassette was inserted immediately downstream. Properly targeted mice were crossed to cre expressing mice to excise the floxed selection cassette and exon 1. (J:186292)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hspb8 Mutation: 17 strains or lines available

References

• Original: J:186292 Qiu H, et al., H11 kinase/heat shock protein 22 deletion impairs both nuclear and mitochondrial functions of STAT3 and accelerates the transition into heart failure on cardiac overload. Circulation. 2011 Jul 26;124(4):406-15
• All: 1 reference(s)