Tg(Crx-cre)352Gla
Transgene Detail

Summary

• Symbol: Tg(Crx-cre)352Gla
• Name: transgene insertion 352, Tom Glaser
• MGI ID: MGI:5433216
• Synonyms: Crx>Cre Tg (line 352)
• Transgene: Tg(Crx-cre)352Gla Location: unknown
• Alliance: Tg(Crx-cre)352Gla page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F2 or (B6;129-Gt(ROSA)26Sor^tm1Sho/J x (C57BL/6 x SJL)F1)

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Crx-cre)352Gla expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Crx

• Mutation details: A construct with a 2.4 kb fragment of the Crx gene containing the promoter and proximal regulatory region driving cre cDNA followed by an SV40 polyadenylation sequence. The construct was generated from a plasmid that contained the Crx-Atoh7-IRES-cre sequence by excising the Atoh7 and IRES pieces. The purified Crx-cre transgene was injected into oocytes. 2 founders and 2 lines were obtained, crossed to GFP reporter mice, and analyzed for GFP and cre production. A representative line, 352, was analyzed in detail. (J:186563)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Crx (species not specified) Summary of all recombinase alleles driven by Crx. Comparative matrix view of recombinase activities

Expression

In Mice Carrying this Mutation:

14 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:186563 Prasov L, et al., Pushing the envelope of retinal ganglion cell genesis: Context dependent function of Math5 (Atoh7). Dev Biol. 2012 Aug 15;368(2):214-30
• All: 6 reference(s)