Them5^tm1Hem
Targeted Allele Detail

Summary

• Symbol: Them5^tm1Hem
• Name: thioesterase superfamily member 5; targeted mutation 1, Brian A Hemmings
• MGI ID: MGI:5433219
• Gene: Them5 Location: Chr3:94249406-94254659 bp, + strand Genetic Position: Chr3, 40.52 cM, cytoband F2
• Alliance: Them5^tm1Hem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186657
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The translated portion of exon 1 and all of exon 2 were replace with an IRES-LacZ-neomycin cassette. (J:186657)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Them5 Mutation: 12 strains or lines available

References

• Original: J:186657 Zhuravleva E, et al., Acyl coenzyme A thioesterase Them5/Acot15 is involved in cardiolipin remodeling and fatty liver development. Mol Cell Biol. 2012 Jul;32(14):2685-97
• All: 1 reference(s)