Tg(Crx-Atoh7,-cre)60Gla
Transgene Detail

Summary

• Symbol: Tg(Crx-Atoh7,-cre)60Gla
• Name: transgene insertion 60, Tom Glaser
• MGI ID: MGI:5433290
• Transgene: Tg(Crx-Atoh7,-cre)60Gla Location: unknown
• Alliance: Tg(Crx-Atoh7,-cre)60Gla page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F2 or (B6;129-Gt(ROSA)26Sor^tm1Sho/J x (C57BL/6 x SJL)F1)

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Crx-Atoh7,-cre)60Gla expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Crx (MGI:1194883)

• Mutation details: A BAC transgenic targeting construct containing an Atoh7-IRES-cre-FRT-amp-FRT cassette with an SV40 polyA sequence was used to target the Crx gene in BAC clone RP23-81H17 by recombineering methods in bacteria. The cassette was inserted after the ATG initiation codon in exon 2. The amp selection cassette was deleted in targeted clones. The purified BAC construct was injected into fertilized oocytes. More than 3 lines were generated and line 764 was more extensively characterized. (J:186563)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Crx (mouse) Summary of all recombinase alleles driven by Crx. Alliance mouse Crx gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:186563 Prasov L, et al., Pushing the envelope of retinal ganglion cell genesis: Context dependent function of Math5 (Atoh7). Dev Biol. 2012 Aug 15;368(2):214-30
• All: 2 reference(s)