Tg(Crx-cre)764Gla
Transgene Detail

Summary

• Symbol: Tg(Crx-cre)764Gla
• Name: transgene insertion 764, Tom Glaser
• MGI ID: MGI:5433291
• Transgene: Tg(Crx-cre)764Gla Location: unknown
• Alliance: Tg(Crx-cre)764Gla page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F2 or (B6;129-Gt(ROSA)26Sor^tm1Sho/J x (C57BL/6 x SJL)F1)

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Crx-cre)764Gla expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Crx (MGI:1194883)

• Mutation details: A targeting construct containing a cre-FRT-amp-FRT cassette with an SV40 polyA sequence was used to target the Crx gene in BAC clone RP23-81H17 by recombineering methods in bacteria. The cassette was inserted after the ATG initiation codon in exon 2. The amp selection cassette was deleted in targeted clones. The purified BAC-cre construct was injected into fertilized oocytes. More than 3 lines were generated and line 60 was more extensively characterized. (J:186563)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Crx (mouse) Summary of all recombinase alleles driven by Crx. Alliance mouse Crx gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:186563 Prasov L, et al., Pushing the envelope of retinal ganglion cell genesis: Context dependent function of Math5 (Atoh7). Dev Biol. 2012 Aug 15;368(2):214-30
• All: 4 reference(s)