Chn2^tm1.1Alk
Targeted Allele Detail

Summary

• Symbol: Chn2^tm1.1Alk
• Name: chimerin 2; targeted mutation 1.1, Alex L Kolodkin
• MGI ID: MGI:5433303
• Gene: Chn2 Location: Chr6:54016917-54278797 bp, + strand Genetic Position: Chr6, 26.54 cM, cytoband B3
• Alliance: Chn2^tm1.1Alk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186252
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. A lacZ-IRES with a 5' lox511 and a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the floxed neo cassette and reverted the lacZ cassette to allow for expression of lacZ. (J:186252)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chn2 Mutation: 46 strains or lines available

References

• Original: J:186252 Riccomagno MM, et al., The RacGAP beta2-Chimaerin Selectively Mediates Axonal Pruning in the Hippocampus. Cell. 2012 Jun 22;149(7):1594-606
• All: 3 reference(s)