Chn2^tm2.1Alk
Targeted Allele Detail

Summary

• Symbol: Chn2^tm2.1Alk
• Name: chimerin 2; targeted mutation 2.1, Alex L Kolodkin
• MGI ID: MGI:5433304
• Synonyms: Chn2^I130A
• Gene: Chn2 Location: Chr6:54016917-54278797 bp, + strand Genetic Position: Chr6, 26.54 cM, cytoband B3
• Alliance: Chn2^tm2.1Alk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186252
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 6 was replaced with one in which three silent mutations introduced a Bsp1286I restriction site for diagnostic purposes and two mutations resulted in the amino acid substitution of alanine for isoleucine at position 130 (I130A). Cre-mediated recombination removed the floxed neo cassette inserted downstream of the modified exon 6. (J:186252)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chn2 Mutation: 46 strains or lines available

References

• Original: J:186252 Riccomagno MM, et al., The RacGAP beta2-Chimaerin Selectively Mediates Axonal Pruning in the Hippocampus. Cell. 2012 Jun 22;149(7):1594-606
• All: 2 reference(s)