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Ly75tm1.1(HBEGF/EGFP)Ksat
Targeted Allele Detail
Summary
Symbol: Ly75tm1.1(HBEGF/EGFP)Ksat
Name: lymphocyte antigen 75; targeted mutation 1.1, Katsuaki Sato
MGI ID: MGI:5433322
Synonyms: Cd205dtr
Gene: Ly75  Location: Chr2:60122447-60213617 bp, - strand  Genetic Position: Chr2, 34.54 cM
Alliance: Ly75tm1.1(HBEGF/EGFP)Ksat page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:186395
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Ly75tm1.1(HBEGF/EGFP)Ksat expresses 1 gene
 
Mutation detailsA human diphtheria toxin receptor (HBEGF or DTR) with a 5' IRES was fused to EGFP and inserted into the 3' UTR. A self-excising neo cassette removed itself. (J:186395)
Generation of the Ly75tm1.1(HBEGF/EGFP)Ksat allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ly75 Mutation:  78 strains or lines available
References
Original:  J:186395 Fukaya T, et al., Conditional ablation of CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11288-93
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory