Tlx3^tm2.1Qima
Targeted Allele Detail

Summary

• Symbol: Tlx3^tm2.1Qima
• Name: T cell leukemia, homeobox 3; targeted mutation 2.1, Qiufu Ma
• MGI ID: MGI:5433363
• Synonyms: Tlx3^F
• Gene: Tlx3 Location: Chr11:33150752-33153589 bp, - strand Genetic Position: Chr11, 19.21 cM, cytoband A5
• Alliance: Tlx3^tm2.1Qima page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186470
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT flanked neo cassette and loxP site were inserted into intron 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:186470)

Expression

In Mice Carrying this Mutation:

39 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlx3 Mutation: 14 strains or lines available

References

• Original: J:186470 Lopes C, et al., Tlx3 and runx1 act in combination to coordinate the development of a cohort of nociceptors, thermoceptors, and pruriceptors. J Neurosci. 2012 Jul 11;32(28):9706-15
• All: 4 reference(s)