Hey2^tm2.1Mtc
Targeted Allele Detail

Summary

• Symbol: Hey2^tm2.1Mtc
• Name: hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 2.1, Michael T Chin
• MGI ID: MGI:5433499
• Synonyms: CHF1^Flox
• Gene: Hey2 Location: Chr10:30708355-30718779 bp, - strand Genetic Position: Chr10, 17.19 cM, cytoband A4
• Alliance: Hey2^tm2.1Mtc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186570
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exons 2 and 3 floxed. (J:186570)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hey2 Mutation: 31 strains or lines available

References

• Original: J:186570 Liu Y, et al., Transcription factor CHF1/Hey2 regulates EC coupling and heart failure in mice through regulation of FKBP12.6. Am J Physiol Heart Circ Physiol. 2012 May 1;302(9):H1860-70
• All: 2 reference(s)