Cripto^tm1.1Gmin
Targeted Allele Detail

Summary

• Symbol: Cripto^tm1.1Gmin
• Name: cripto, EGF-CFC family member; targeted mutation 1.1, Gabriella Minchiotti
• MGI ID: MGI:5433707
• Synonyms: cripto^F78A
• Gene: Cripto Location: Chr9:110768676-110775226 bp, - strand Genetic Position: Chr9, 60.79 cM
• Alliance: Cripto^tm1.1Gmin page

Arrested development in Cripto^tm1.1Gmin/Cripto^tm1.1Gmin embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186907
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Hypomorph, Inserted expressed sequence) Mutation: Insertion Mutation details: A floxed pgk-neo cassette was inserted upstream of exon 3 and an F78A mutation was introduced via homologous recombination. Cre mediated recombination removed the neo cassette. Protein expression is confined to proximal epiblast in homozygous embryos. (J:186907)

Generation of the Cripto^tm1.1Gmin allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cripto Mutation: 55 strains or lines available

References

• Original: J:186907 D'Andrea D, et al., Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction. J Cell Biol. 2008 Feb 11;180(3):597-605
• All: 2 reference(s)