Gpx4^tm3Marc
Targeted Allele Detail

Summary

• Symbol: Gpx4^tm3Marc
• Name: glutathione peroxidase 4; targeted mutation 3, Marcus Conrad
• MGI ID: MGI:5433757
• Synonyms: mGPx4^-
• Gene: Gpx4 Location: Chr10:79883000-79892273 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Gpx4^tm3Marc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186906
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: An inframe translation STOP was introduced into the mitochondrial leader sequence (TTAA to ATTAATTC). A recombinase flanked neo cassette was inserted downstream of exon 7. Western blot analysis confirmed the absence of mitochondria specific isoform in the testes. (J:186906)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpx4 Mutation: 82 strains or lines available

References

• Original: J:186906 Schneider M, et al., Mitochondrial glutathione peroxidase 4 disruption causes male infertility. FASEB J. 2009 Sep;23(9):3233-42
• All: 1 reference(s)