Cbx3^tm1Pbs
Targeted Allele Detail

Summary

• Symbol: Cbx3^tm1Pbs
• Name: chromobox 3; targeted mutation 1, Prim B Singh
• MGI ID: MGI:5433765
• Synonyms: Cbx3^hypo
• Gene: Cbx3 Location: Chr6:51447596-51460684 bp, + strand Genetic Position: Chr6, 24.89 cM, cytoband B-C
• Alliance: Cbx3^tm1Pbs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186901
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 4. Western blot analysis confirmed reduced protein expression in mouse embryonic fibroblasts. This allele is hypomorphic. (J:186901)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cbx3 Mutation: 61 strains or lines available

References

• Original: J:186901 Brown JP, et al., HP1gamma function is required for male germ cell survival and spermatogenesis. Epigenetics Chromatin. 2010;3(1):9
• All: 3 reference(s)